Skip to main content
. 2015 Jan 9;115(6):2453–2481. doi: 10.1021/cr5004248

Table 2. hnRNPs Contain Putative Poly(ADP-ribose)-Binding Motifsa.

hnRNPs functions putative PAR-binding site
hnRNP A1 splicing, mRNA transport, telomere biogenesis 99-GAHLTVKKIF-108
hnRNP A2/B1 splicing, mRNA trafficking 106-GAHVTVKKLF-115
hnRNP C1/C2 transcript packaging, splicing, mRNA stability 92-RGKAGVKRSA-101
hnRNP G splicing 118-GTRGPPSRGG-127
hnRNP H splicing 210-YDRPGAGRGY-219
hnRNP K transcription, stability, translation 261-FDRMPPGRGG-270
hnRNP E1 stability, translation 25-VGSIIGKKGE-34
hnRNP A3 mRNA trafficking, telomere biogenesis not known
hnRNP L mRNA export, stability, riboswitch not known
hnRNP M splicing 212-DYKVGWKKLK-221
hnRNP U nuclear retention not known
a

Proteomic analyses have found that heterogeneous nuclear ribonucleoproteins (hnRNPs) contain putative PAR-binding motifs.135,211