. 2015 Jan 9;115(6):2453–2481. doi: 10.1021/cr5004248

Table 4. Phenotypic Outcomes of Parp1^–/– Mice upon Metabolic Stress.

stress	exon	background	body weight	fat deposition	glucose metabolism	other phenotypes
STZ	2	129/Sv × C57BL/6	N/A	N/A	maintained	protection against STZ-induced diabetes^176b
STZ	1	129/Sv × ICR	N/A	N/A	maintained	protection against STZ-induced diabetes^176a
HFD	2	129/SvlmJ	increased	increased	impaired	hyperleptinemia¹⁷⁷
	4	C57BL/6	decreased	decreased	improved	enhanced energy expenditure¹⁷⁸
	2	C57BL/6	decreased	decreased	impaired	higher hepatic lipid accumulation and dyslipidemia¹⁸³

Table 4. Phenotypic Outcomes of Parp1–/– Mice upon Metabolic Stress.