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Cancer-derived H3K27M mutants inhibit PRC2 activity. (a) Molecular architecture of PRC2 according to Ciferri et al.218 (b) PRC2 inhibition by K27M causes aberrant gene expression. PRC2 serves to silence certain genes through its HMT activity (left). In K27M tumor cells (right), trimethylation at Lys27 is dramatically reduced, preventing gene repression. K27me3 marks are shown as green flags, K27M mutant as a red circle. (c) Structure of Lys, Met, and Nle.
