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Site-directed footprinting to map nucleosome positioning. (a) Activated disulfide reagent (7) to attach an EDTA derivative to cysteine residues (top) and hydroxyl radical generation by the Fenton reaction employing Fe(II) (bottom). (b) Model of the preferred cleavage site (red) upon introducing a sensitizer at H4S47C (yellow). The nucleosome dyad is indicated with a white arrow. (c) Structure of N-(1,10-phenanthroline-5-yl)iodoacetamide (8) in complex with Cu(I).
