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Schematic of the signaling cascade that controls chromatin condensation during mitosis. Decompacted chromatin, partially labeled with a photo-cross-linker (BPA, red star), is acetylated at H4K16 (yellow flag). Upon entry into M phase, aurora B kinase phosphorylates H3S10 (blue lollipop), which recruits the HDAC Hst2p (blue). Once H4K16 is deacetylated, chromatin compacts, observed by an H2A–H4 cross-link (green star).
