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. 2014 Oct 20;115(6):2296–2349. doi: 10.1021/cr5003529

Figure 4.

Figure 4

Recognition of acetyllysine residues by bromodomains. (a) Binding pocket of the GCN5 BD in complex with an H4 peptide acetylated at Lys16 (green). A hydrogen bond between Asn407 of the BD (black) and the acetyl group is indicated with a dotted line; pdb code: 1E6I. (b) Architecture of the double-BD module of TAFII250. The acetyllysine binding pocket of each lobe is indicated in red; pdb code: 1EQF. (c) Simultaneous binding of two acetyllysine residues by BD1 of Brdt. A synthetic H4 peptide bearing K5ac and K8ac is depicted in green with hydrogen-bonding networks indicated by dotted lines; pdb code: 2WP2. Surfaces in subfigures (a) and (c) are shown in electrostatic rendering (blue, positive; white, neutral; red, negative). Ordered water molecules are shown as red spheres.