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Auxiliary-based semisynthesis of uH2B. (a) Site-specific ubiquitylation of histone peptides. An amino-thiol ligation auxiliary permits ligation of a ubiquitin α-thioester to a glycine residue attached to the side-chain of Lys120. (b) Semisynthesis of native, full-length uH2B via a two-step ligation. MesNa = sodium 2-mercaptoethanesulfonate, TCEP = tris(2-carboxyethyl)phosphine.
