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. 2014 Oct 20;115(6):2296–2349. doi: 10.1021/cr5003529

Figure 51.

Figure 51

Plasticity in the stimulation of Dot1 by histone ubiquitylation. The canonical ubiquitylation site of H2B is indicated in black (K120, white arrow), permissive sites in green (H2A-G22 and H2B-K125), prohibitive sites in red (H2B-K108 and H2B-K116). The substrate residue (H3K79) of Dot1 is highlighted in blue.