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. 2015 Jan 16;115(6):2419–2452. doi: 10.1021/cr500452k

Figure 12.

Figure 12

Structures of CBP bromodomain bound to ligands. The purified CBP bromodomain (residues 1081–1197, shown in a rainbow blue to red) is shown bound to (A) histone H4 residues 14–28 acetylated at K20 (PDB 2RNY); (B) p53 residues 367–386 acetylated at K382 (PDB 1JSP); (C) the compound ischemin (PDB 2L84); and (D) the compound dimethylisoxazole (PDB 3SVH). Peptide ligands are shown in gray (A,B) or stick models colored by atom (C,D and acetyl-lysines in A,B). All structures are based on solution NMR except for (D), which is from X-ray crystallography (1.8 Å).