Table 1.

Brief Summary of HCV Treatment Guidelines in Patients Who Are HCV Genotype 1–Positive and Treatment-Naïve²⁵

Treatment of HCV Genotype 1a
	LDV/SOF	OBV/PTV/r + DSV + RBV	SOF + SMV ± RBV
Treatment duration	12 weeks	12 weeks (no cirrhosis) or 24 weeks (cirrhosis)	12 weeks (no cirrhosis) or 24 weeks (cirrhosis)
Recommendation level	Class I, level A	Class I, level A	Class IIa, level B
Treatment of HCV Genotype 1b
	LDV/SOF	OBV/PTV/r + DSV*	SOF + SMV
Treatment duration	12 weeks	12 weeks (no cirrhosis)	12 weeks (no cirrhosis) or 24 weeks (cirrhosis)
Recommendation level	Class I, level A	Class I, level A	Class IIa, level B

DSV = dasabuvir; HCV = hepatitis C virus; LDV = ledipasvir; OBV = ombitasvir; PTV = paritaprevir; r = ritonavir; RBV = ribavirin; SMV = simeprevir; SOF = sofosbuvir

^*The addition of ribavirin is recommended in patients with cirrhosis.