Table 2.

Brief Summary of HCV Treatment Guidelines in Patients Who Are HCV Genotype 1–Positive And Failed Prior PEG/RBV Therapy²⁵

Recommended Treatment in Patients Without Cirrhosis
	LDV/SOF	OBV/PTV/r + DSV*		SOF + SMV ± RBV
Treatment duration	12 weeks	12 weeks		12 weeks
Recommendation level	Class I, level A	Class I, level A		Class IIa, level B

Recommended Treatment in Patients With Compensated Cirrhosis
	LDV/SOF	OBV/PTV/r + DSV + RBV	LDV/SOF + RBV	SOF + SMV ± RBV
Treatment duration	24 weeks	24 weeks	12 weeks	24 weeks
Recommendation level	Class I, level A	Class I, level A	Class I, level B	Class IIa, level B

DSV = dasabuvir; HCV = hepatitis C virus; LDV = ledipasvir; OBV = ombitasvir; PEG = pegylated interferon; PTV = paritaprevir; r = ritonavir; RBV = ribavirin; SMV = simeprevir; SOF = sofosbuvir

^*The addition of ribavirin is recommended in patients with genotype 1a HCV infection.