Table 1.
Patient Demographics and Histopathologic Features of Well-Differentiated Neuroendocrine Tumors Grouped by Site of Origin
| N=46 | Pancreas (N=11) | Stomach (N=6) | Small Bowel (N=19) | Appendix (N=6) | Colon/Rectum (N=4) | p-value |
|---|---|---|---|---|---|---|
| Age (mean ± SD) | 46.2±16.8 | 57.8±16.4 | 60.7±10.6 | 43.5±15.7 | 58.8±5.6 | 0.028* |
|
| ||||||
| Sex | ||||||
| Male | 4 (36%) | 1 (17%) | 6 (35%) | 2 (33%) | 2 (50%) | 0.874 |
| Female | 7 (64%) | 5 (83%) | 11 (65%) | 4 (67%) | 2 (50%) | |
|
| ||||||
| Tumor Size (median (range)) | 4.0 (1.3–6.5) | 1.4 (0.5–5.0) | 2.4 (0.7–11.0) | 0.7 (0.2–2.0) | 2.0 (0.8–4.5) | <0.001* |
|
| ||||||
| Stage | ||||||
| I | 2 (25%) | 1 (20%) | 0 (0%) | 6 (100%) | 2 (50%) | <0.001* |
| II | 3 (38%) | 3 (60%) | 1 (5%) | 0 (0%) | 0 (0%) | |
| III | 1 (12%) | 0 (0%) | 7 (39%) | 0 (0%) | 0 (0%) | |
| IV | 2 (25%) | 1 (20%) | 10 (56%) | 0 (0%) | 2 (50%) | |
|
| ||||||
| Any Mets | 3 (27%) | 1 (17%) | 17 (89%) | 0 (0%) | 2 (50%) | <0.001* |
|
| ||||||
| LN Mets | 2 (18%) | 0 (0%) | 16 (89%) | 0 (0%) | 0 (0%) | <0.001* |
|
| ||||||
| Distant Mets | 2 (18%) | 1 (17%) | 11 (61%) | 0 (0%) | 2 (50%) | 0.022* |
|
| ||||||
| Vasc. invasion | 1 (9%) | 1 (17%) | 10 (53%) | 1 (17%) | 0 (0%) | 0.053 |
|
| ||||||
| Positive Margins | 1 (25%) | 0 (0%) | 1 (7%) | 0 (0%) | 0 (0%) | 0.492 |
|
| ||||||
| Ki67 index [median, (range)] | 5% (1–16%) | 4% (1–5%) | 1.5% (1–10%) | 2% (1–5%) | 5.5% (2–10%) | 0.131 |
qPCR = quantitative PCR, IHC = immunohistochemistry, Vasc. = vascular, Mets = metastases, LN = lymph node.
*
p-value with statistical significance