Table 1.
Effect of oral administration of TS extract fractions, rofecoxib, and diclofenac on abdominal writhing in mice induced by intraperitoneal injection of acetic acid
| Dose | Writhing response* | Percentage of inhibition | P value |
|---|---|---|---|
| (No. of writhes in 30 min) | |||
| Control by Vehicle (10 ml/kg) | 127.8 ± 13.46 | ||
| TSL1 (1 g/kg) | 76.9 ± 20.9 | 39.9% | < 0.001 |
| TSL2 (1 g/kg) | 102.9 ± 28.3 | 19.5% | < 0.05 |
| TSL3 (1 g/kg) | 112.8 ± 14.8 | 11.7% | 0.052 |
| TSL4 (1 g/kg) | 117.4 ± 16.4 | 8.1% | 0.188 |
| TSL5 (1 g/kg) | 113.3 ± 14.6 | 11.4% | 0.057 |
| TSL1 (0.3 g/kg) | 79.3 ± 21.7 | 38.0% | < 0.001 |
| TSL1 (0.1 g/kg) | 67.8 ± 20.7 | 46.9% | < 0.001 |
| TSL1 (0.03 g/kg) | 85.0 ± 24.9 | 31.1% | < 0.001 |
| TSL1 (0.01 g/kg) | 113.1 ± 17.2 | 11.7% | 0.092 |
| Rofecoxib (1.5 mg/kg) | 93.4 ± 13.2 | 26.9% | < 0.01 |
| Rofecoxib (5 mg/kg) | 84.6 ± 11.0 | 33.8% | < 0.001 |
| Diclofenac (5 mg/kg) | 84.9 ± 13.1 | 33.5% | < 0.001 |
| Diclofenac (10 mg/kg) | 72.0 ± 14.5 | 43.7% | < 0.001 |
*Values are expressed as mean ± S.D. (n = 8).