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. 2015 Mar 16;2015:959684. doi: 10.1155/2015/959684

Figure 5.

Figure 5

Blockade of the anti-HBV effect of IFN-CSP by JAK inhibitors. Confluent HepG2.2.15 cells were pretreated for 1 h with JAK inhibitor or not and then incubated with either IFN-CSP or IFNα2b for 3 days. Hepatitis B surface antigen (HBsAg; a) and hepatitis B e antigen (HBeAg; b) in the culture supernatants were analyzed by enzyme-linked immunosorbent assay (ELISA). HBV-DNA (c) in the culture supernatants was measured by real-time quantitative PCR. Data represent the mean ± SEM of three experiments. * P < 0.05 versus untreated controls ** P < 0.01 versus untreated controls, # P < 0.05 versus no JAK inhibitor controls, ## P < 0.01 versus no JAK inhibitor controls.