Table 2.
Multivariate analysis of the blood inflammatory biomarkers for the selected recruited subjects.
| Blood marker | Least square mean (95% CI) | P value | |||||
|---|---|---|---|---|---|---|---|
| Nonusers | COC | CVC | Global test | Nonuser versus COC | Nonuser versus CVC | COC versus CVC | |
| MCP-1 (pg/mL) | 285 (195, 375) | 189 (104, 274) | 161 (53, 270) | 0.22 | 0.14 | 0.12 | 0.69 |
| IL-6 (pg/mL) | 1.1 (0.8, 1.5) | 0.9 (0.6, 1.2) | 1.1 (0.6, 1.5) | 0.64 | 0.38 | 0.83 | 0.55 |
| sTNF-RI (pg/mL) | 975 (845, 1105) | 950 (829, 1071) | 805 (649, 962) | 0.25 | 0.79 | 0.13 | 0.14 |
| sTNF-RII (pg/mL) | 4310 (3777, 4842) | 4295 (3799, 4791) | 4311 (3672, 4951) | 1.00 | 0.97 | 1.00 | 0.98 |
| sCD40L (ng/mL) | 2937 (1843, 4031) | 5259 (4240, 6277) | 2806 (1493, 4119) | <0.01* | <0.01* | 0.89 | <0.01* |
| CRP (mg/L) | 0.6 (−0.2, 1.4) | 3.6 (2.9, 4.4) | 2.9 (2.0, 3.9) | <0.0001* | <0.0001* | <0.001* | 0.24 |
| Lymphocytes (10e9/L) | 1.93 (1.67, 2.19) | 2.31 (2.05, 2.57) | 2.27 (1.94, 2.60) | 0.14 | 0.0521 | 0.15 | 0.85 |
Note: a P value of <0.05 is indicated by ∗. Multivariate analysis adjusted for age, race, alcohol consumption, regular sleeping habit, and family history of cardiovascular disease (CVD) and stroke.
MCP-1: monocytes chemotactic protein-1, IL-6: interleukin-6, sCD40L: soluble CD40 ligand, sTNF-RI: soluble tissue necrosis factor receptor I, sTNF-RII: soluble tissue necrosis factor receptor II, and CRP: C-reactive protein.