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. Author manuscript; available in PMC: 2015 Mar 30.
Published in final edited form as: Mol Cell. 2015 Feb 19;57(4):575–576. doi: 10.1016/j.molcel.2015.02.006

Figure 1. Nutrients Regulate Global miRNA Biogenesis through an mTORC1-Mdm2-Drosha Pathway.

Figure 1

(Left) Under nutrient sufficiency mTORC1 is activated, and it increases the levels of the ubiquitin E3 ligase Mdm2. mTORC1 may control Mdm2 levels through a p53-dependent and -independent pathway. Mdm2 ubiquitinates and targets the miRNA-processing enzyme Drosha for proteasomal-dependent degradation. This results in a global decrease of miRNA biogenesis. (Right) Under nutrient deficiency mTORC1 is not active and Mdm2 levels are low. Drosha levels are elevated leading to an increase in global miRNA biogenesis.