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H2O2-induced death of peripheral lymphocytes in the presence of 3-ABA, a PARP-1 inhibitor. PARP-1 inhibition induced a marked protection from H2O2-induced death, with a significantly reduced degree of protection in severe AD lymphocytes (A). B: Apoptosis/necrosis ratios measured in the presence of PARP-1 inhibition in the three groups of patients. Symbols as in Fig. (1A).
