Table 1.
Influences of APOE alleles, TOMM40 polyT repeat of VL length, ethnicity, and gender on the age of onset of sIBM using standard adjusted linear regression analysis
| Variable | Count | Age of onset (mean ± SD), y | Adjusted analysisa |
|
|---|---|---|---|---|
| Regression coefficient (95% CI) | p Valueb | |||
| Ethnicity | ||||
| Non-Caucasian | 16 | 56.7 ± 5.7 | Reference | |
| Caucasian | 141 | 60.0 ± 10.0 | 2.8 (−2.3, 7.9) | 0.28 |
| Gender | ||||
| F | 52 | 57.9 ± 10.4 | Reference | |
| M | 105 | 60.6 ± 9.3 | 2.7 (−0.5, 5.9) | 0.095 |
| APOE | ||||
| ε2/ε4c | 6 | 56.8 ± 5.8 | ||
| ε3/ε3 | 99 | 60.2 ± 9.8 | Reference | |
| ε2/ε3 | 19 | 56.9 ± 10.0 | −2.9 (−7.7, 1.9) | 0.23 |
| ε3/ε4 and ε4/ε4 | 33 | 60.4 ± 9.7 | 1.6 (−2.4, 5.7) | 0.43 |
| TOMM40 polyT | ||||
| No VL carriage | 74 | 58.1 ± 9.7 | Reference | |
| VL carriage | 83 | 61.2 ± 9.6 | 3.7 (0.4, 6.9) | 0.027 |
| APOE-TOMM40 | ||||
| ε3/ε3 and polyT non-VL carriage | 38 | 57.3 ± 9.9 | Reference | |
| ε3/ε3 and polyT VL carriage | 61 | 62.0 ± 9.4 | 4.9 (1.1, 8.7) | 0.013 |
Key: APOE, apolipoprotein E; CI, confidence interval; F, female; M, male; SD, standard deviation, sIBM, sporadic inclusion body myositis; TOMM40, translocase of outer mitochondrial membrane 40; VL, very long.
a
Each analysis was adjusted for gender, ethnicity, tissue, and genetic factors, except for the variable under study.
b
p value < 0.05 was considered statistically significant (marked in bold).
c
ε2/ε4 was not included in the regression analysis for APOE alleles and the age of onset.