Skip to main content
. Author manuscript; available in PMC: 2015 Mar 30.
Published in final edited form as: Exp Hematol. 2008 Mar 17;36(5):655–666. doi: 10.1016/j.exphem.2008.01.002

Figure 7.

Figure 7

Competitive repopulating ability of hematopoietic stem/progenitor (HSC/P) cells lacking expression of Hck, Fgr, or Lyn. (A) Peripheral blood (PB) lineage chimerism in mice transplanted with wild-type (WT), Hck−/−, Lyn−/−, or Fgr−/− low-density bone marrow (BM) cells and 1 × 105 competitor cells. Mean chimerism for each genotype was calculated and the data generated at 4 months after transplantation are summarized in bar graphs. Experiments were repeated twice with four to five mice in each group. Shown are data from 1:1 ratio. Mean ± standard deviation, *p < 0.05 WT vs Lyn−/−. (B) Representative dot blots indicating multilineage engraftment of WT and Lyn−/− stem cells into myeloid and lymphoid lineages. PB cells were stained with antibodies that recognize myeloid and lymphoid lineages. Shown are percentages of donor cells from a representative mouse engrafted with WT or Lyn−/− BM cells and competitors.