Table II.
Summary of treatment administration
| Dose and Schedule | Median No. Cycles | Range of Cycles | Patients Requiring Dose Reductions | Patients With Delayed Count Recovery1 |
|---|---|---|---|---|
| 1 mg × 14 days | 3 | 1-5 | 0/3 | 0/3 |
| 1 mg × 21 days | 5 | 2-5 | 0/3 | 0/3 |
| 2 mg × 21 days | 5 | 1-5 | 0/3 | 0/3 |
| 3 mg × 21 days | 4 | 1-5 | 1/6 | 2/6 |
| 4 mg × 21 days | 3 | 2-5 | 2/6 | 1/6 |
| 6 mg × 21 days | 4 | 4 | 1/1 | 0/1 |
1
Attributable to clofarabine. Delayed count recovery defined as > 28 days of absolute neutrophil count <1000/mm3, or platelets <75,000/mm3, which required drug discontinuation.