Table 1.
Univariate (a) analysis for neutrophil engraftment.
| Parameter | Engraftment rate (95% CI) | P value |
|---|---|---|
|
| ||
| UCB unit cryopreservation (years) | ||
| 0–2 | 94% (89–98) | |
| 2.1–4 | 96% (90–99) | |
| >4 | 92% (85–97) | 0.21 |
|
| ||
| TNC (×107/kg) | ||
| <2.5 | 90% (78–97) | |
| ≥2.5 | 95% (92–97) | 0.02 |
|
| ||
| CD34+ (×105/kg) | ||
| <2.5 | 89% (79–96) | |
| ≥2.5 | 96% (93–98) | <0.01 |
|
| ||
| Post thaw viability | ||
| <75% | 92% (88–96) | |
| ≥75% | 96% (91–99) | 0.86 |
|
| ||
| CFU-GM (×106/kg) | ||
| <5.0 | 92% (87–96) | |
| ≥5.0 | 97% (93–99) | <0.01 |
|
| ||
| HLA matching | ||
| 6/6 match | 93% (86–97) | |
| 5/6 or less | 95% (91–97) | 0.15 |
|
| ||
| ABO Match | ||
| Match | 92% (86–96) | |
| Minor mismatch | 96% (91–99) | |
| Major mismatch | 94% (88–98) | 0.03 |
|
| ||
| Conditioning regimen | ||
| Myeloablative | 95% (66–82) | |
| Reduced intensity | 92% (58–93) | 0.30 |
|
| ||
| Year of transplant | ||
| Prior to 2006 | 95% (90–98) | |
| 2006–2013 | 94% (89–97) | 0.08 |
|
| ||
| Recipient CMV | ||
| Positive | 92% (87–96) | |
| Negative | 95% (91–98) | 0.52 |
|
| ||
| Recipient gender | ||
| Male | 95% (91–98) | |
| Female | 93% (88–97) | 0.71 |
|
| ||
| Recipient age (years) | ||
| <18 | 94% (91–97) | |
| ≥18 | 93% (83–98) | 0.14 |
CFU-GM – colony forming unit granulocyte macrophage; CMV – cytomegalovirus; HLA – human leukocyte antigen; TNC – total nucleated cell; UCB – umbilical cord blood