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. Author manuscript; available in PMC: 2015 Mar 30.
Published in final edited form as: In Vivo. 2013 Nov-Dec;27(6):669–684.

Table II.

Outline of sepsis treatment.

Method Function Treatment in animal models Clinical trial in patients with sepsis
Corticosteroids Suppress cytokine production Reduced mortality
Hemodiafiltration Removes cytokines Restored blood pressure and respiratory function
Androstenediol Reduces cytokine production Increases survival Unknown
Benzylsulfone derivatives Suppress cytokine production Increases survival Unknown
Soluble TNF-α receptor Blocks TNF-α activity Reduces mortality No beneficial effects
TNF-α neutralizing antibody Blocks TNF-α activity Reduces morbidity and mortality No beneficial effects
IL-17A neutralizing antibody Blocks IL-17 activity Improves survival Unclear
IL-18 neutralizing antibody Blocks IL-18 activity Reduces lung injury Unknown
IL-10 neutralizing antibody Blocks IL-10 activity Improves survival Unknown
GM-CSF Relieves immunosuppression Improved clinical parameters, but not survival

IL: Interleukin; GM-CSF: granulocyte-macrophage colony-stimulating factor; TNF: tumor necrosis factor.