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. Author manuscript; available in PMC: 2015 Mar 30.
Published in final edited form as: J Cell Biochem. 2011 Feb;112(2):463–475. doi: 10.1002/jcb.22934

Fig. 2.

Fig. 2

The mitochondrial death pathway in human melanoma cell lines. A,B: Cell cycle-apoptosis analysis of melanocytes, FEMX, LU1205, and WM9 melanoma cells, which were treated sodium arsenite (5 µM) in the presence or absence of either NGF-β (100 ng/ml) or EGF (50 ng/ml) for the next 24 h; non-treated control cells were designed as (Con). Caspase inhibitors, zVAD, LEHD, and IETD (50 µM), were additionally used. After treatment, cells were stained with PI and analyzed by FACS assay. Error bars represent mean ± SD (Student's t-test, P < 0.05). C: Effects of sodium arsenite on oxygen consumption of melanocytes (M-cytes), FEMX and LU1205 melanoma cells 24h after treatment. D: Clonogenic survival assay of melanoma cell lines 12 days after sodium arsenite treatment.