Table 1. Comparison of the design of 2 randomised controlled trials for vasculitis: MYPAN versus MYCYC.

Trial name and study population	MYPAN a : PAN b in children (≥4 and ≤ 18 years)	MYCYC c : ANCA d associated vasculitis in adults & children (8 children, 132 adults)
Hypothesis	MMF e is not inferior (<10% absolute difference) to intravenous CYC f for induction of remission	MMF is not inferior (<12% absolute difference) to intravenous CYC for induction of remission
Entry criteria	i) Must fulfil classification criteria for PAN; ii) 1or more major PVAS g items and/or 3 or more minor PVAS items; iii) Must be newly diagnosed patients	i) Chronic inflammatory disease lasting at least 4 weeks; characteristic histology on biopsy and/or a positive ANCA; ii) 1 or more major BVAS h items and/or 3 or more minor PVAS items; iii) Must be newly diagnosed patients
Primary endpoint	Remission within 6 months defined as PVAS 0/63 on 2 consecutive readings at least one month apart on protocol steroid taper	Remission within 6 months defined as BVAS 0/63 on 2 consecutive readings at least one month apart on protocol steroid taper

^aMYPAN: Mycophenolate mofetil for childhood polyarteritis nodosa;

^bPAN: polyarteritis nodosa;

^cMYCYC: Mycophenolate mofetil versus cyclophosphamide for ANCA associated vasculitis;

^dANCA: anti neutrophil cytoplasmic antibodies;

^eMMF: Mycophenolate mofetil;

^fCYC: cyclophosphamide;

^gPVAS: Paediatric Vasculitis Activity Score;

^hBVAS: Birmingham Vasculitis Activity Score.