Table 1. Comparison of the clinical and demographic data of the newly diagnosed patients Vs. relapsed acute promyelocytic leukemia patients.
| Demographic Parameters | Newly Diagnosed N = 98 N (%) / Median (Range) | Relapsed N = 28 N (%) / Median (Range) | P-value |
|---|---|---|---|
| Age (years) | 28 (2–60) | 31 (8–54) | 0.997 |
| Sex: Male | 48 (49) | 25 (89.3) | 0.000 |
| WBC x 109/Lt | 14.5 (0.5–290) | 3.5 (0.5–24.90) | 0.000 |
| Platelet x 109/Lt | 17 (3–85) | 31.5 (6–248) | 0.006 |
| RT-PCR | - | - | - |
| bcr1 | 59 (60.2) | 21(75) | 0.311 |
| bcr2 | 2 (2) | 0 | |
| bcr3 | 37 (37.8) | 7 (25) | |
| Lactate dehydrogenase (IU/Lt)) | 748 (291–2700) | 554 (284–1155) | 0.006 |
| Fibrinogen (mg/dl) | 161 (25–689) | 163 (70–1122) | 0.975 |
| Additional CTG finding | - | - | - |
| Yes | 34 (36.6) | 11 (61.1) | 0.068 |
| No | 59 (63.4) | 7 (38.9) | |
| IC Bleed (at diagnosis or during induction therapy) | - | - | - |
| Yes | 16 (16.3) | 0 | 0.022 |
| No | 82 (83.7) | 28 (100) | |
| Differentiation syndrome (during induction therapy) | - | - | - |
| Yes | 13 (13.3) | 2 (7.11) | 0.518 |
| No | 85 (86.7) | 26 (92.9) | |
| Blood product utilization induction | - | - | - |
| PRC ^ units | 24 (0–85) | 16 (0–48) | 0.027 |
| FFP* units | 12 (0–72) | 7 (0–60) | 0.156 |
| Cryoprecipitate units | 6 (0–59) | 3 (0–30) | 0.456 |
^ PRC = platelet rich concentrate
*FFP = Fresh frozen plasma