Table 1.

Demographic and Clinical Characteristics

Demographic Characteristics	MDD	HC	P value1
N	41	29
Age (mean years ± SD)	15.7 ± 2	16.0 ± 2	0.5
Sex (male/female)	9/32 (78% female)	7/22 (76% female)	0.8
Right Handed – n (%)	32 (91%; n = 35)	25 (93%; n = 27)	0.8
Ethnicity – n (%)			0.1
Caucasian	28 (68%)	16 (55 %)
African American	5 (12%)	1 (4%)
Hispanic	4 (10%)	4 (14%)
Asian	0	2 (70%)
Native American	0	1 (3%)
Other	4 (10%)	5 (17%)
Current Comorbidities – n (%)	27 (68%)	N/A
Attention Deficit and Hyperactive Disorder	6 (15%)	N/A
Generalized Anxiety Disorder	16 (39%)	N/A
Obsessive-Compulsive Disorder	1 (3%)	N/A
Oppositional Defiant Disorder	2 (5%)	N/A
Post-Traumatic Stress Disorder	2 (5%)	N/A
Social Anxiety	3 (8%)	N/A
Dysthymia	2 (5%)	N/A
Panic Disorder	2 (5%)	N/A
Specific Phobia	3 (8%)	N/A
Social Phobia	4 (10%)	N/A
Medication History
Med-Naïve – n (%)	30 (73%)	N/A
Past Antidepressant Use –n (%)	8 (57%)	N/A
Past Stimulants Use	4 (29%)	N/A
Past Antipsychotic Use	2 (14%)	N/A
Illness History, Description, Etc
Duration of illness (mean months±SD)	10 ± 11 (n = 39) 1	N/A
Global Assessment of Functioning (mean±SD)	54 ± 9	N/A
Positive Family History	28 (82%; n = 34)	N/A
Clinical Severity
CDRS-R (T-scores mean±SD)	77 ± 6 (n = 34)	N/A
BDI-II Most Severe (mean±SD)	29 ± 13	3 ± 4	<0.0001
IDAS Dimension scores	n = 37	n = 28
General Depression Score	57 ± 16	27 ± 4	<0.0001
Dysphoria Score	28 ± 9	12 ± 3	<0.0001
Lassitude Score	19 ± 6	9 ± 3	<0.0001
Insomnia Score	5 ± 6	7 ± 1	<0.0001
Suicidality Score	13 ± 7	6 ± 0.2	<0.0001
Loss of Appetite Score	7 ± 3	3 ± 1	<0.0001
Appetite Gain Score	6 ± 4	4 ± 2	0.008
Ill Temper Score	12 ± 6	6 ± 2	<0.0001
Well-being Score	18 ± 6	27 ± 6	<0.0001
Social Anxiety Score	123 ± 5	6 ± 1	<0.0001
Panic Score	14 ± 7	8 ± 1	<0.0001
Traumatic Intrusion Score	8 ± 4	4 ± 0.5	<0.0001

¹P values resulted from chi square analyses (sex, ethnicity) or independent samples t-tests (all others).

²Exact number of subjects are provided