| 1 |
FASN |
FASN |
Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. Indicated as a poor prognosis in breast and prostate cancer. |
| 2 |
Claudin-7 |
CLDN7 |
Claudins make up tight junction strands. |
| 3 |
PR |
PGR |
Progesterone receptor, Transcription Factor |
| 4 |
TIGAR |
C12ORF5 |
Regulates p53 tumor suppressor pathway and glycolysis |
| 5 |
GATA3 |
GATA3 |
Transcription factor |
| 6 |
NDRG1_pT346 |
NDRG1 |
A member of the NDRG family functions in growth, differentiation, and cell survival |
| 7 |
AR |
AR |
Androgen receptor (AR). Transcription Factor |
| 8 |
PREX1 |
REX1 |
Downstream of Heterotrimeric G proteins (Guanine nucleotide exchange factor) |
| 9 |
PEA15_pS116 |
PEA15 |
Implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin-sensitive glucose transport in insulin-responsive cells. Its activation is mediated through binding to multiple proteins, including ERK1&2, RSK2, Akt, FADD, and Caspase-8. |
| 10 |
Cyclin_B1 |
CCNB1 |
Cyclin B1 regulates mitosis. Cyclin B1 levels rise during S phase and G2, and peak at mitosis. |
| 11 |
ER-alpha |
ESR1 |
Estrogen receptor, Transcription Factor |
| 12 |
AMPK_alpha |
PRKAA1 |
Involved in energy homeostasis regulation |
| 13 |
Acetyl-a-Tubulin-Lys40 |
|
The cytoskeleton consists of three types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Acetylation of α-tubulin at Lys40 is required for dynamic cell shape remodeling, cell motility, tubulin stability and terminal branching of cortical neurons |
| 14 |
Rab-25 |
Rab-25 |
A member of Rab11 family possesses small Ras-like GTPase activity. Increased Rab25 expression is associated with aggressive growth in ovarian and breast cancer, where Rab25 may inhibit apoptosis and promote cancer cell proliferation and invasion through regulation of vesicle transport and cellular motility. |
| 15 |
Chk2 |
CHEK2 |
Kinase acts downstream of ATM/ATR involving in DNA damage checkpoint control, embryonic development, and tumor suppression |
| 16 |
E-Cadherin |
CDH1 |
A member of transmembrane glycoprotein superfamily, Mediate calcium-dependent cell-cell adhesion and normal tissue development. |
| 17 |
ACC1 |
ACACA |
Key enzyme in the biosynthesis and oxidation of fatty acids. Involved in energy homeostasis regulation |
| 18 |
GAPDH |
GAPDH |
Glyceraldehyde 3-phosphate dehydrogenase |
| 19 |
PKC-alpha_pS657 |
PRKCA |
PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions |
| 20 |
TRFC |
TFRC |
Transferrin Receptor |
| 21 |
Cyclin_E1 |
CCNE1 |
Cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. The cyclin E/E2F complex is detected primarily during the G1 phase of the cell cycle and decreases as cells enter S phase. E2F is known to be a critical transcription factor for expression of several S phase specific proteins. |
| 22 |
CD20 |
CD20 |
A surface molecule of B-lymphocyte during the differentiation of B-cells into plasma cells |
| 23 |
GAB2 |
GAB2 |
A docking protein, which mainly mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors. |
