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| Drug Parameter | Before Coadministration (range) | At start of Coadministration (range) | At steady state of Coadministration (range) |
|---|---|---|---|
| Median daily sirolimus dose, mg | 4.6 (1-12) | 0.5 (0.1-1.2) | 0.6 (0-2) |
| Median daily sirolimus dose reduction, % | 90 (80-92) | 84 (0-100) | |
| Median serum sirolimus trough level, ng/mL | 5.8 (0-47.6) | 6.1 (1-14.2) |
