Supplementary Fig. 3.

DaTSCAN of subject II:1. An abnormal scan, which shows bilateral reduced striatal uptake of [¹²³I]FP-CIT, worse on the left side, as demonstrated by the arrow. Images 1–7 represent transverse sections through the brain, where 1 is the most superior and 7 the most inferior section. A normal DaTSCAN shows symmetrical bilateral striatal uptake which confers a comma-shaped configuration. There should be only minor background activity. The head of comma represents caudate activity whilst tail is due to uptake within putamen. In this example there is loss of uptake within each putamen. Caudate activity especially that on the left is also diminished. Note increased background activity. An MRI excluded a possible structural cause for these findings.