Table 8. Voxel-based analysis.

	Cluster-level			Peak-level
	FWE corr.	uncorr.	voxels	FWE corr.	uncorr.	Coordinates
						x	y	z
Focal lesion	0.048	0.072	883	0.006	<0.001	3.3	0	−3.4
Herpes encephalitis	<0.001	<0.001	15747	0.017	<0.001	−3.8	−11.8	−9.6
				0.068	<0.001	−2.0	−9.2	−8.8
				0.072	<0.001	1.5	−10.4	−7.2

Increased uptake of [¹¹C]PK11195 in the intervention group as compared to the healthy rats. For the focal lesion test, Sprague-Dawley rats were divided in a healthy control group (n = 11) and rats stereotaxic injected with saline (n = 10). For the herpes encephalitis model, Wistar rats were divided in a healthy group (n = 19) and infected rats (n = 14). For the interpretation of group differences, T-maps data were interrogated at p = 0.001 (uncorrected) and an extent threshold of 200 voxels. Only cluster with p<0.05 family-wise error (FWE) corrected were considered significant.