Table 1.

Clinical and laboratory features of patients admitted with malignant infiltration of the liver presenting as ALF.

Demographics
Characteristics	Overall	Breast cancer N=8	Lymphoma/leukemia n=11	Other solid tumors n=8
Age (years)	47.1 ±13.9	49.2 ±12.3	44.7 ±14.3	48.2 ±14.2
Sex, % female	67%	100%	36%	75%
Race % Caucasian	67%	63%	73%	63%
% African-American	26%	25%	18%	37%
% Asian-American	4%	12%	-	-
% Hispanic	4%	-	9%	-
Lab features at presentation (Median)
AST (IU/L)	963 (125–7197)	948 (370–5706)	2466 (125–7197)	367 (142–3266)
ALT (IU/L)	673 (46–6904)	466 (46–2439)	1161 (112–6904)	427 (141–1677)
Alkaline phosphatase (IU/L)	393 (110–3301)	547 (166–902)	280 (110–2043)	367 (254–3301)
Total bilirubin (mg/dL)	12.3 (1.3–30.7)	12.7 (1.3–30.7)	12.2 (5.1–26.0)	14.4 (2.7–27.0)
Creatinine (mg/dL)	1.9 (0.5–5.6)	1.8 (0.5–3.3)	2.1 (0.6–5.6)	1.7 (0.7–5.4)
INR	2.1 (1.4–3.9)	2.2 (1.6–3.9)	2.0 (1.4 –3.1)	2.0 (1.6–3.4)
WBC (× 103/mm3)	12.0 (1.8–47.6)	13.3 (8.5–21.9)	8.8 (1.8–47.6)	13.5 (5.8–29.1)
Hgb (g/dL)	9.7 (7.4–16.0)	10.8 (7.5–14.8)	8.6 (7.4 –16.0)	9.5 (7.5–12.5)
Plts × 103 uL	106 (11–303)	101 (11–259)	74 (12–141)	130 (28–303)
Clinical status at presentation
% Intubated on arrival	11% (3/27)	25% (2/8)	9% (1/11)	0% (0/8)
% Required hemodialysis	7% (2/27)	-	9% (1/11)	12% (1/8)
% Infected	4% (1/27)	12% (1/8)	-	-
% Grade 3–4 Encephalopathy	22% (6/27)	25% (2/8)	27% (3/11)	13% (1/8)
Outcomes
% Salvage chemotherapy	11% (3/27)	13% (1/8)	9% (1/11)	13% (1/8)
% OLT	7% (2/27)	0% (0/8)	9% (1/11)	13% (1/8)
% Alive at 3 weeks post-study enrollment	11% (3/27)	13% (1/8)	9% (1/11)	13% (1/8)
Median time to death after admission (days)	10.5 (3–28)	7 (3–13)	12 (6–28)	14 (8–21)

All laboratory values refer to those noted on admission.

WBC= White blood cell count; INR = International Normalized Ratio; OLT= Orthotopic liver transplant.