Table 2. Genotype distribution of IL 18–137 G/C polymorphism in Controls, CAD patients and FDRS (N = 700).
| Model | Genotype | Controls N = 300 n (%) | CAD N = 300 n (%) | CAD Odds Ratio | FDRS N = 100 n (%) | FDRS Odds Ratio | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| χ2 | Odds ratio (95% CI) | p-Value | χ2 | Odds ratio(95% CI) | p-Value | |||||
| Co-dominant | GG | 176(58.7) | 168(56) | 0.001 | 1 | 0.99 | 65(65) | 2.34 | 1 | 0.12 |
| GC | 105(35) | 102(34) | 1.02 (0.72–1.44) | 25(25) | 0.64 (0.38–1.09) | |||||
| CC | 19(6.3) | 30(10) | 1.8 | 1.65 (0.90–3.05) | 0.17 | 10(10) | 2.38 | 1.43 (0.63–3.23) | 0.12 | |
| Dominant | GGGC-CC | 176(58.7) 124(41.3) | 168(56) 132(44) | 0.33 | 1.12 (0.81–1.54) | 0.56 | 65(65) 35(35) | 1 | 0.76 (0.48–1.22) | 0.31 |
| Recessive | GG-GCCC | 281(93.7) 19(6.3) | 270(90) 30(10) | 2.22 | 1.64 (0.90–2.99) | 0.13 | 90(90) 10(10) | 1 | 1.64 (0.74–3.66) | 0.31 |
| Overdominant | GG-CCGC | 195(65) 105(35) | 198(66) 102(34) | 0.02 | 0.96 (0.68–1.34) | 0.86 | 75(75) 25(25) | 2.9 | 0.62 (0.37–1.03) | 0.08 |
| Log-Additive | - - - - | - - - - | - - - - | - - - - | 1.17 (0.91–1.50) | 0.23 | - - - - | - - - - | 0.93 (0.65–1.34) | 0.71 |
| Allele frequency | GC | 457(76) 143(24) | 438(73) 162(27) | 1.42 | 1.182 (0.91–1.53) | 0.23 | 155(78) 45(22) | 0.08 | 0.92 (0.6295–1.354) | 0.77 |
| Minor allele frequency | C | 0.24 | 0.27 | - - - - | 0.22 | - - - - | ||||
| HWE (p-value) | 0.53 | 0.019 | - - - - | 0.007 | - - - - | |||||