Table 1. Fraction of the observed homo-dimeric interfaces during five independent MD simulations of the μ-OR/μ-OR, δ-OR/δ-OR, and κ-OR/κ-OR systems.
| Interface | δ-OR/δ-OR | κ-OR/κ-OR | μ-OR/μ-OR | |||
|---|---|---|---|---|---|---|
| TM1,2,H8/TM1,2,H8 | 17.4 | (9,27.4) | 26.0 | (16.8,36.2) | 7.8 | (2.2,16.6) |
| TM1,2/TM4,5 | 41.3 | (29.4,53.3) | 27.2 | (18.1,37.7) | 9.8 | (3.3,18.8) |
| TM1,2/TM5,6 | 31.7 | (21,43.5) | 22.1 | (13.7,31.8) | 37.3 | (24.7,50.9) |
| TM4,5/TM4,5 | 1.6 | (0,5.7) | ― | ― | ― | ― |
| TM4,5/TM5,6 | 7.9 | (2.6,15.7) | 1.3 | (0,4.7) | 1.9 | (0,7) |
| TM5/TM5 | ― | ― | 23.3 | (14.6,33.3) | 43.2 | (30.3,56.8) |
Best estimate of the fraction of each homo-dimeric arrangement and its (2.5%,97.5%) confidence intervals (in parenthesis) are calculated as reported in the Methods section.