Table 4. Association rates of OR hetero-dimers formed during five independent MD simulations of the δ-OR/μ-OR and δ-OR/κ-OR systems.
| Interface | δ-OR/κ-OR | δ-OR/μ-OR | ||
|---|---|---|---|---|
| TM1,2,H8/TM1,2,H8 | 15.43 | (4.9,31.5) | 9.10 | (1.9,22.1) |
| TM1,2/TM4,5 | 12.35 | (3.2,26.2) | 3.09 | (0.2,11.4) |
| TM1,2/TM5,6 | 12.35 | (3.2,27) | 9.26 | (1.9,22.2) |
| TM4,5/TM1,2 | 15.43 | (4.9,30.9) | 6.17 | (0.8,17.4) |
| TM4,5/TM5,6 | 15.43 | (4.9,30.9) | ― | ― |
| TM5/TM1,2 | ― | ― | 6.17 | (0.6,17.1) |
| TM5/TM5 | ― | ― | 15.28 | (4.9,31.5) |
| TM5,6/TM1,2 | 9.26 | (1.9,22.2) | 3.09 | (0.2,11.6) |
Estimated kon rates (in μm2/s) along with (2.5,97.5) confidence intervals.