Table 11. Results of the feature analysis for the GPCR_NO dataset.
| Feature | P-value | PS | Positive Median | Unlabelled Median | Feature | P-value | PS | Positive Median | Unlabelled Median |
|---|---|---|---|---|---|---|---|---|---|
| Alanine | 4.75 × 10−02 | 0.56 | 0.08 | 0.07 | Positively Charged | 1.92 × 10−01 | 0.54 | 0.11 | 0.11 |
| Arginine | 5.63 × 10−03 | 0.59 | 0.05 | 0.05 | Sequence Length | 2.87 × 10−03 | 0.59 | 408 | 373 |
| Asparagine | 1.77 × 10−01 | 0.54 | 0.04 | 0.04 | PEST Motifs | 2.40 × 10−01 | 0.53 | 0 | 0 |
| Aspartic Acid * | 7.06 × 10−04 | 0.61 | 0.03 | 0.03 | Low Complexity Regions | 4.71 × 10−01 | 0.48 | 2 | 2 |
| Cysteine | 4.56 × 10−01 | 0.48 | 0.03 | 0.03 | Hydrophobicity * | 1.84 × 10−04 | 0.38 | 0.31 | 0.43 |
| Glutamic Acid | 5.66 × 10−02 | 0.56 | 0.03 | 0.03 | Isoelectric Point | 1.81 × 10−01 | 0.54 | 9.02 | 8.68 |
| Glutamine | 4.25 × 10−01 | 0.47 | 0.03 | 0.03 | Signal Peptide | 5.96 × 10−01 | 0.48 | 0 | 0 |
| Glycine | 4.89 × 10−01 | 0.52 | 0.05 | 0.05 | O-glycosylation Sites | 7.97 × 10−02 | 0.51 | 0 | 0 |
| Histidine * | 9.56 × 10−09 | 0.32 | 0.02 | 0.02 | N-glycosylation Sites | 2.04 × 10−01 | 0.54 | 2 | 2 |
| Isoleucine | 4.73 × 10−01 | 0.52 | 0.07 | 0.06 | Phosphoserine Sites | 7.94 × 10−02 | 0.53 | 0 | 0 |
| Leucine * | 1.44 × 10−04 | 0.38 | 0.12 | 0.13 | Phosphothreonine Sites | 5.07 × 10−03 | 0.53 | 0 | 0 |
| Lysine | 7.18 × 10−02 | 0.56 | 0.04 | 0.04 | Phosphotyrosine Sites | 2.78 × 10−01 | 0.51 | 0 | 0 |
| Methionine | 4.69 × 10−01 | 0.52 | 0.02 | 0.02 | Total Phosphorylation Sites | 3.51 × 10−02 | 0.55 | 0 | 0 |
| Phenylalanine | 2.43 × 10−03 | 0.40 | 0.05 | 0.06 | Transmembrane α-helices | 9.58 × 10−01 | 0.50 | 7 | 7 |
| Proline | 1.77 × 10−03 | 0.60 | 0.05 | 0.04 | Exposed α-helices | 5.36 × 10−02 | 0.44 | 0.09 | 0.10 |
| Serine | 1.82 × 10−01 | 0.46 | 0.08 | 0.08 | Buried α-helices | 6.55 × 10−02 | 0.44 | 0.47 | 0.51 |
| Threonine | 6.27 × 10−01 | 0.48 | 0.06 | 0.06 | β Strands | 4.84 × 10−02 | 0.44 | 0.03 | 0.03 |
| Tryptophan | 7.86 × 10−01 | 0.49 | 0.02 | 0.02 | 3’ Untranslated | 2.41 × 10−01 | 0.48 | 0 | 0 |
| Tyrosine | 4.28 × 10−01 | 0.47 | 0.03 | 0.03 | 5’ Untranslated | 1.85 × 10−01 | 0.47 | 0 | 0 |
| Valine | 5.84 × 10−01 | 0.48 | 0.08 | 0.08 | Nonsynonymous Coding | 2.98 × 10−01 | 0.53 | 2 | 1 |
| Aliphatic | 3.39 × 10−03 | 0.41 | 0.26 | 0.27 | Synonymous Coding | 4.03 × 10−01 | 0.49 | 0 | 0 |
| Aromatic * | 6.54 × 10−06 | 0.36 | 0.12 | 0.14 | Binary PPIs | 3.70 × 10−01 | 0.48 | 0 | 0 |
| Charged | 2.63 × 10−03 | 0.60 | 0.18 | 0.17 | Alternative Transcripts | 6.69 × 10−03 | 0.58 | 1 | 1 |
| Negatively Charged | 1.64 × 10−03 | 0.60 | 0.07 | 0.06 | Paralogues | 7.19 × 10−01 | 0.50 | 0 | 0 |
| Non-polar | 3.51 × 10−02 | 0.43 | 0.61 | 0.63 | Body Sites Expressed In | 1.73 × 10−01 | 0.54 | 12 | 11 |
Shaded features are ones for which the PS≥0.5. The amino acid, exposed α-helix, buried α-helix and β strand features are all proportions (e.g. the Alanine feature for a protein is the number of alanine residues in the sequence divided by the sequence length), while all other features are absolute numbers.
Features with significant differences are indicated with an *.