Table 1.

Dosing and pharmacological characteristics of three low-molecular weight heparins in chronic kidney disease

	Dalteparin [26]	Enoxaparin [27]	Tinzaparin [28]
Treatment indications (dose)	ACS (120 IU/kg BD), VTE (200 IU/kg OD)	ACS (1 mg/kg BD), VTE (1.5 mg/kg OD)	VTE (175 IU/kg OD)
Dosing advice in CKD 4/5	No dose adjustment advised except with anti-Xa level for eGFR <30 mL/min	Dose reduction to 1 mg/kg once daily if eGFR <30 mL/min	No dose reduction needed if eGFR >20 mL/min. Dose adjust as per anti-Xa level if <20 mL/min
Anti-Xa:IIa ratio	2.2	3.9	2.8
Average molecular weight (Da)	5000	4500	5500–7500

OD, once daily; BD, twice daily; VTE, venous thromboembolism.