Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Exp Eye Res. 2015 Apr;133:126–131. doi: 10.1016/j.exer.2014.07.007

Figure 2. Pathway of tyrosine sulfation.

Figure 2

Free sulfate enter the cell via sulfate transporters and are rapidly converted to 3’-phosphoadenosine 5’-phosphosulfate (PAPS) by 3’-phosphoadenosine 5’-phosphosulfate synthase. 3’-phosphoadenosine 5’-phosphosulfate is then translocated into the trans-Golgi through 3’-phosphoadenosine 5’-phosphosulfate translocase. This allows the tyrosylprotein sulfotransferase to then add the free sulfate from the high energy source, 3’-phosphoadenosine 5’-phosphosulfate, to a newly synthesized protein. The tyrosine sulfated protein is secreted to become a free member of the extracellular matrix or re-associate with the producing cell directly or through interactions with membrane proteins.