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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Exp Eye Res. 2015 Apr;133:100–111. doi: 10.1016/j.exer.2014.07.015

Figure 2.

Figure 2

The sclera of lumican/fibromodulin deficient mice. Photographs of whole eyes of wildtype mice (Lum+/+ Fmod +/+) (A) and lumican/fibromodulin deficient mice (Lum−/− Fmod−/−) (B), demonstrating significantly higher axial length of deficient mice as compared with wildytpe mice. Collagen fibril morphology in the posterior sclera of wildtype mice (C) and Lum−/− Fmod −/− deficient mice (D). Collagen fibrils from deficient mice displayed abnormal small-to very large-diameter fibrils with irregular contours. Bar in B = 2 mm; Bar in D = 500 nm. From: Chakravarti S., et al. Ocular and scleral alterations in gene-targeted lumican-fibromodulin double-null mice. Invest Ophthalmol Vis Sci 44: 2422–2432. 2003 Reproduced with permission © Association for Research in Vision and Ophthalmology.