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Effects of pre-diabetes (A), short-term diabetes (B), and long-term diabetes (C) on endothelium-dependent vasodilation of the femoral principal nutrient artery alone, in the presence of the nitric oxide synthase inhibitor L-NAME, and in the presence of L-NAME and the cyclooxygenase inhibitor indomethacin (Indo). Values are means ± SE, n = 14–15/group. *Mean is different from age-matched non-diabetic control animals (P<0.05).
