Table 1.

Body mass, blood glucose and insulin concentrations, and femoral bone mineral density (BMD).

	7 wk Control	7 wk Pre- diabetic	13 wk Control	13 wk Short- term	20 wk Control	20 wk Long- term
Body Mass (g)	128±5	174±6*	276±8	341±14*	369±5	402±13*
Glucose (mg/dL)	86±4	104±8	88±5	219±17*	94±4	242±14*
Insulin (ng/mL)	1.3±0.2	4.7±1.0*	1.2±0.1	5.2±1.4*	1.5±0.1	1.6±0.1
Total BMD (mg/cm3)	459±4	471±6	562±7	513±16	617±11	487±7*
Cancellous BMD (mg/cm3)	350±9	383±9*	317±7	309±20	326±10	227±23*
Cortical BMD (mg/cm3)	1,163±4	1,152±4	1,333±3	1,324±2*	1,386±3	1,368±3*

Values are mean ± S.E.

^*Denotes significant differences from age-matched lean controls (p< 0.05).