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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Innate Immun. 2014 Mar 20;21(2):203–214. doi: 10.1177/1753425914526074

Figure 2.

Figure 2

Assessment of changes in the gene expression of the different inflammasomes and their related components in MEM after NTHi infection. Mining gene chip microarray data showed significant and early time-dependent increases in transcripts of the inflammasome targets IL-1β and IL-18 after NTHi infection (A). This is accompanied by up-regulation of various inflammasome receptor mRNAs (B), including NLRP-3, RIG-1, AIM-2 and NLRP-4. Up-regulation of the mRNA for the adaptor molecule ASC and various caspases during NTHi induced OM (C) provides the remaining substrates for the inflammasome. The transcripts of various molecules known to activate the different inflammasomes are also increased in (D) and (E), as are those of inflammasome regulators (F). Data are represented numerically in Supplementary Table S1.