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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Innate Immun. 2014 Mar 20;21(2):203–214. doi: 10.1177/1753425914526074

Figure 7.

Figure 7

ME expression of genes related to Th17 cell differentiation. There is evidence that caspase-1 activation can play a role in tissue proliferation, mediated by Th17 cytokines. Others have noted these genes are down-regulated in caspase-1 knockout mice in stomach mucosa.46 Gene array data indicated that mRNA up-regulation of Th17 cytokines and receptors possibly play an early role in the innate immune response of the ME. This provided evidence that these genes may play a role in stimulating mucosal hyperplasia in the ME, and would be hypothesized to be reduced in mice unable to activate caspase-1, as in the case of the Asc−/− knockout mice used in this study.