Table 1.
Schedule of assessments
| Assessment | Baseline | Follow-up |
|---|---|---|
| Demographics | ||
| Age, sex | X | |
| Education | X | |
| Working status | X | |
| Marital status | X | |
| Structured assessment of TIA/TNA presentation | ||
| Duration of symptoms | X | |
| Number of episodes in week before inclusion | X | |
| Focal symptoms* | X | |
| Nonfocal symptoms* | X | |
| Incident focal symptoms* | X | |
| Incident nonfocal symptoms* | X | |
| Medical history | ||
| Hypertension | X | X |
| Dyslipidemia | X | X |
| Diabetes mellitus | X | X |
| Atrial fibrillation | X | X |
| Other cardiovascular diseases† | X | |
| First-degree relatives with cardiovascular disease | X | |
| Smoking status | X | X |
| Alcohol consumption | X | X |
| Drug abuse | X | X |
| Hypercoagulability | X | |
| Acute infection | X | |
| Migraine | X | |
| Previous TIA/TNA | X | |
| Carotid endarterectomy | X | X |
| Epilepsy | X | X |
| Depression | X | X |
| Current medication use | X | X |
| Incident cardiovascular events† | X | |
| Incident TIA, cerebral infarction or hemorrhage | X | |
| Physical examination | ||
| Length and weight, BMI | X | |
| Blood pressure | X | |
| Neurological examination | X | |
| ECG | ||
| (Paroxysmal) atrial fibrillation | X | |
| Ischemia | X | |
| Left ventricular hypertrophy | X | |
| Fasting laboratory investigations | ||
| Glucose | X | |
| Lipid profile | X | |
| Creatinine | X | |
| Neuropsychological assessment | ||
| Global cognitive function | ||
| Mini Mental State Examination | X | |
| Frontal Assessment Battery | X | X |
| Episodic memory | ||
| Rey Auditory Verbal Learning Test | X | X |
| Executive function | ||
| Verbal fluency | X | X |
| Stroop Color Word Test (interference score) | X | X |
| Brixton Spatial Anticipation Test | X | X |
| Information processing speed | ||
| Symbol-Digit Modalities Test | X | X |
| Stroop Color Word Test (Cards I and II) | X | X |
| Attention | ||
| Verbal Series Attention Test | X | X |
| Subjective cognitive failures | ||
| Cognitive failures Questionnaire | X | X |
| Depressive symptoms | ||
| Hospital Anxiety and Depression Scale | X | X |
| Sleep disorders | ||
| Scales for Outcomes in Parkinson’s Disease - Sleep | X | X |
| Fatigue | ||
| Checklist on Individual Strength | X | X |
| Prior cognitive performance | ||
| Informant Questionnaire on Cognitive Decline in the Elderly | X | X |
| MRI | ||
| Anatomical sequences (T1, T2, FLAIR, T2*) | X | X |
| Diffusion-weighted imaging | X | |
| MR angiography | X | |
| Susceptibility-weighted imaging | X | |
| Diffusion tensor imaging | X | |
| Resting-state functional MRI | X |
Empty cells indicate no assessment. BMI indicates body-mass index; FLAIR, fluid-attenuated inversion recovery; TNA, transient neurological attack; ToF, time-of-flight.
*Presence of 18 predefined symptoms, both focal and nonfocal (see also Table 2).
†Myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, valvular heart disease and peripheral revascularization procedures.