Table 2.
Association analysis of AKR1B10 variants in the Sorbs population
| AKR1B10 genotype | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs10232478 | rs782881 | rs1834150 | rs3778828 | rs4732036 | |||||||||||
| Genotype ( N ) | CC (76) | CT (230) | TT (195) | CC (114) | AC (263) | AA (150) | TT (115) | TA (257) | AA (171) | AA (37) | GA (201) | GG (293) | CC (49) | TC (210) | TT (280) |
| Association analysis with anthropometric traits | |||||||||||||||
| BMI (kg/m2) | 25.96 ± 3.83 | 26.42 ± 4.94 | 25.99 ± 4.09 | 26.5 ± 4.9 | 25.9 ± 4.4 | 26.2 ± 4.1 | 26.2 ± 4.1 | 26 ± 4.5 | 26.1 ± 4.1 | 26.4 ± 4 | 25.9 ± 4 | 26.2 ± 4.7 | 26.0 ± 4.9 | 25.9 ± 4.2 | 26.1 ± 4.4 |
| p-value | n.s. | n.s. | n.s. | n.s. | n.s. | ||||||||||
| Waist (cm) | 87.17 ± 11.70 | 88.92 ± 13.6 | 88.91 ± 13.37 | 87.80 ± 13.1 | 88.22 ± 12.8 | 89.18 ± 13.3 | 87.20 ± 11.8 | 88.64 ± 13.2 | 88.76 ± 13.2 | 87.78 ± 12.6 | 88.60 ± 12.8 | 88.20 ± 13.2 | 88.12 ± 14.9 | 88.46 ± 12.9 | 88.33 ± 12.8 |
| p-value | n.s. | "0.001 | "0.004 | n.s. | n.s. | ||||||||||
| Hip (cm) | 101.6 ± 7.3 | 103.6 ± 9.2 | 102.4 ± 7.4 | 102.61 ± 9.1 | 106.22 ± 55.8 | 102.77 ± 7.4 | 102.37 ± 7.8 | 106.39 ± 56.4 | 102.39 ± 7.4 | 104.14 ± 7.5 | 102.17 ± 7 | 105.99 ± 53.0 | 102.35 ± 9.4 | 106.67 ± 62.3 | 102.82 ± 7.9 |
| p-value | n.s. | n.s. | n.s. | n.s. | n.s. | ||||||||||
| WHR | 0.86 ± 0.09 | 0.86 ± 0.09 | 0.87 ± 0.1 | 0.85 ± 0.1 | 0.85 ± 0.1 | 0.87 ± 0.1 | 0.85 ± 0.1 | 0.86 ± 0.1 | 0.86 ± 0.1 | 0.84 ± 0.1 | 0.86 ± 0.1 | 0.85 ± 0.1 | 0.86 ± 0.1 | 0.86 ± 0.1 | 0.86 ± 0.1 |
| p-value | n.s. | n.s. | n.s. | n.s. | n.s. | ||||||||||
| Association analysis with eating behavior factors | |||||||||||||||
| Disinhibition | 4.95 ± 2.88 | 4.53 ± 3.16 | 3.81 ± 2.7 | 4.9 ± 3.11 | 4.3 ± 3.02 | 4.04 ± 2.92 | 4.93 ± 3.16 | 4.33 ± 2.95 | 3.94 ± 2.89 | 4.65 ± 3.04 | 4.25 ± 2.99 | 4.41 ± 3.03 | 4.29 ± 2.92 | 4.29 ± 3.12 | 4.43 ± 2.94 |
| p-value | °0.003 | °0.032 "0.037 | °0.006 #0.027 "0.022 | n.s. | n.s. | ||||||||||
| Hunger | 4.09 ± 2.94 | 4.04 ± 2.84 | 3.66 ± 2.66 | 4.26 ± 2.86 | 3.83 ± 2.86 | 3.92 ± 3.10 | 4.17 ± 2.88 | 3.85 ± 2.85 | 3.95 ± 3.04 | 3.99 ± 3.16 | 3.99 ± 2.81 | 3.93 ± 2.98 | 3.84 ± 2.8 | 4.07 ± 3.05 | 3.88 ± 2.86 |
| p-value | n.s. | n.s. | n.s. | n.s. | n.s. | ||||||||||
| Restraint | 8.79 ± 5.32 | 7.86 ± 4.73 | 7.62 ± 4.92 | 8.52 ± 5.13 | 7.71 ± 4.67 | 7.65 ± 5.05 | 8.52 ± 5.09 | 7.82 ± 4.77 | 7.6 ± 4.9 | 7.42 ± 5.03 | 7.53 ± 4.88 | 8.31 ± 4.83 | 7.8 ± 4.37 | 7.57 ± 4.88 | 8.24 ± 4.96 |
| p-value | n.s. | n.s. | n.s. | °0.048 | n.s. | ||||||||||
| Association analysis with consumer goods | |||||||||||||||
| Smoking | 10.04 ± 8.79 | 10.07 ± 8.13 | 9.45 ± 8.09 | 9.91 ± 8.9 | 10.34 ± 8.18 | 8.4 ± 7.4 | 10.6 ± 9.31 | 9.58 ± 7.95 | 10.02 ± 8.48 | 4.67 ± 3.33 | 10.32 ± 8.98 | 9.89 ± 8.23 | 11.94 ± 8.44 | 9.39 ± 8.35 | 9.89 ± 8.52 |
| p-value | n.s. | #0.044 | n.s. | n.s. | n.s. | ||||||||||
| Alcohol | 2.83 ± 1.2 | 2.78 ± 1.17 | 2.82 ± 1.2 | 2.88 ± 1.18 | 2.76 ± 1.11 | 2.79 ± 1.28 | 2.84 ± 1.23 | 2.77 ± 1.12 | 2.79 ± 1.23 | 2.84 ± 1.30 | 2.8 ± 1.22 | 2.77 ± 1.14 | 2.9 ± 1.19 | 2.82 ± 1.19 | 2.75 ± 1.17 |
| p-value | n.s. | n.s. | n.s. | n.s. | n.s. | ||||||||||
| Coffee | 1.79 ± 0.72 | 1.79 ± 0.76 | 1.74 ± 0.75 | 1.81 ± 0.76 | 1.89 ± 0.82 | 1.75 ± 0.75 | 1.81 ± 0.73 | 1.89 ± 0.82 | 1.71 ± 0.75 | 1.62 ± 0.68 | 1.84 ± 0.82 | 1.81 ± 0.76 | 1.71 ± 0.61 | 1.84 ± 0.79 | 1.80 ± 0.80 |
| p-value | n.s. | n.s. | #0.043 | n.s. | n.s. | ||||||||||
Data are presented as mean ± SD. Type 2 diabetics were excluded. P-values were calculated using additive, dominant (mm + mM vs. MM) and recessive (mm vs mM + MM) model of inheritance using linear regression adjusted for age, gender and lnBMI (except for BMI). Analyses for smoking, alcohol and coffee consumption were adjusted for age and gender; ° = additive model of inheritance; # = dominant model of inheritance; “=recessive model of inheritance; n.s. non-significant; significant P-values are highlighted in bold; N = number of individuals; BMI = Body Mass Index; WHR = Waist-Hip-Ratio.