Figure 2.

Reactivity of untreated (black bars) or lisinopril-treated (Lis; 10 μM; white bars) isolated carotid arteries from 7-week-old MC^+/+ (left panel) and Kit^w/Kit^w-v mice (right panel) to 1 nM Ang I. Each carotid artery preparation was subjected to Ang I only once to preclude the effects of tachyphylaxis. The results are expressed as a percentage of the vasoconstrictor effect induced by 1 nM Ang I when given in the absence of ACE inhibitor pretreatment. Values are mean ± SEM, and n = 6 in each group. Comparisons between Ang I and Lis + Ang I groups were made using the unpaired Student’s t test; *P < 0.001. P < 0.001 for inter-genotype comparisons.