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. 2015 Mar 28;7:9. doi: 10.1186/s13099-015-0056-2

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© Alam et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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In vitro IL-8 production from AGS cells co-cultured with 6 ( dupA 1 ⁺ , cagA ⁺ , vacA ⁺ ) strains, 6 ( dupA 2 ⁺ , cagA ⁺ , vacA ⁺ ) and 6 ( dupA ⁻ , cagA ⁺ , vacA ⁺ ) strains. IL-8 production was significantly higher in dupA1⁺ (cagA ⁺, vacA ⁺) compared to dupA2⁺ (cagA ⁺, vacA ⁺) (536.0 ± 100.4 pg/mL, P = 0.008) and dupA-negative strains (cagA ⁺, vacA ⁺ ) (549.7 ± 104.1 pg/mL, P = 0.009). MOI of H. pylori strain was 100 for 8 hours. Experiments were repeated 3 times for the 18 strains. IL-8 in the supernatant was assayed by an ELISA in duplicate. Data are expressed as mean ± standard error.