Table 1.
Testosterone replacement therapy initiation rates and rate ratios of HIV-infected men in Centers for AIDS Research Network of Integrated Clinical Systems stratified by characteristics at cohort entry.
| N | TRT events | Person-years (py) | Rate (per 1000 py) | IRR | 95% CI | HRa | 95% CI | |
|---|---|---|---|---|---|---|---|---|
| Overall | 14 454 | 1482 | 75 173 | 19.7 | – | 18.7–20.7 | – | – |
| Age (years) | ||||||||
| ≤34 | 4795 | 323 | 25 231 | 12.8 | 1.0 | – | 1.0 | – |
| 35–50 | 8042 | 959 | 42 865 | 22.4 | 1.75 | 1.54–1.98 | 1.58 | 1.37–1.83 |
| >50 | 1617 | 200 | 7077 | 28.3 | 2.21 | 1.85–2.63 | 1.82 | 1.48–2.24 |
| Race | ||||||||
| Nonwhite | 7196 | 508 | 37 063 | 13.7 | 1.0 | – | 1.0 | – |
| White | 7258 | 974 | 38 110 | 25.6 | 1.86 | 1.68–2.07 | 1.72 | 1.51–1.96 |
| HIV risk factor | ||||||||
| Non-MSM | 4535 | 391 | 24 439 | 16.0 | 1.0 | – | 1.0 | – |
| MSM | 9919 | 1091 | 50 734 | 21.5 | 1.34 | 1.20–1.51 | 1.12 | 0.97–1.29 |
| AIDS wasting | ||||||||
| No | 13 940 | 1371 | 72 390 | 18.9 | 1.0 | – | 1.0 | – |
| Yes | 514 | 111 | 2784 | 39.9 | 2.11 | 1.74–2.55 | 2.07 | 1.64–2.60 |
| Hepatitis B | ||||||||
| No | 13 361 | 1354 | 68 930 | 19.6 | 1.0 | – | 1.0 | – |
| Yes | 1093 | 128 | 6244 | 20.5 | 1.04 | 0.87–1.25 | 1.10 | 0.92–1.37 |
| Hepatitis C | ||||||||
| No | 10 983 | 1099 | 55 508 | 19.8 | 1.0 | – | 1.0 | – |
| Yes | 3471 | 383 | 19 666 | 19.5 | 0.98 | 0.88–1.10 | 1.2 | 1.04–1.38 |
| ART type | ||||||||
| None | 4335 | 370 | 24 097 | 15.4 | 1.0 | – | 1.0 | – |
| Non-PI-based | 4819 | 397 | 22 559 | 17.6 | 1.15 | 1.00–1.32 | 1.02 | 0.86–1.21 |
| PI-based | 5300 | 715 | 28 517 | 25.1 | 1.63 | 1.44–1.85 | 1.44 | 1.23–1.68 |
| Nadir CD4+ cell count (cells/µl) | ||||||||
| ≥500 | 2464 | 212 | 12 221 | 17.4 | 1.0 | – | 1.0 | – |
| 350 – 499 | 2515 | 221 | 12 965 | 17.1 | 0.98 | 0.82–1.18 | 1.02 | 0.83–1.26 |
| 201 – 349 | 3434 | 334 | 18 156 | 18.4 | 1.06 | 0.89–1.26 | 1.10 | 0.90–1.34 |
| ≤200 | 6041 | 715 | 31 831 | 22.5 | 1.29 | 1.11–1.51 | 1.23 | 1.02–1.49 |
| HIV RNA (copies/ml) | ||||||||
| ≤500 | 1983 | 195 | 8858 | 22.0 | 1.0 | – | 1.0 | – |
| >500 | 12 471 | 1287 | 66 316 | 19.4 | 0.88 | 0.76–1.02 | 1.03 | 0.86–1.23 |
| BMI (kg/m2) | ||||||||
| ≥30.0 | 1329 | 139 | 6329 | 22.0 | 1.0 | – | 1.0 | – |
| 25.0–29.9 | 3486 | 371 | 17 799 | 20.8 | 0.95 | 0.78–1.15 | 0.87 | 0.72–1.06 |
| 18.5–24.9 | 5891 | 630 | 29 636 | 21.3 | 0.97 | 0.81–1.16 | 0.90 | 0.74–1.08 |
| <18.5 (underweight) | 416 | 51 | 1948 | 26.2 | 1.19 | 0.87–1.64 | 1.14 | 0.82–1.58 |
| Unknown | 3332 | 291 | 19 461 | 15.0 | 0.68 | 0.56–0.83 | – | – |
| Smoking ever | ||||||||
| Yes | 5566 | 483 | 32 422 | 14.9 | 1.0 | – | 1.0 | – |
| Never or unknown | 8888 | 999 | 42 752 | 23.4 | 1.57 | 1.41–1.75 | 1.13 | 0.98–1.31 |
| Alcohol abuse ever | ||||||||
| Yes | 2867 | 265 | 17 097 | 15.5 | 1.0 | – | 1.0 | – |
| Never or unknown | 11 587 | 1217 | 58 076 | 21.0 | 1.35 | 1.19–1.54 | 0.90 | 0.76–1.06 |
ART, antiretroviral therapy; CD4+, CD4+ T-lymphocyte cell count; PI, protease inhibitor.
a
Multivariable Cox regression modelling using all variables listed in the table and CNICS site.