Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 28;34(1):22. doi: 10.1186/s13046-015-0135-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Hu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

HIF-1 activation is sufficient to upregulate DEC2 in osteosarcomas under normoxic condition. A. Bioinformatics analysis of DEC2 promoter reveals that a region with highly acetylated histone H3 at K27 contains potential binding sites for multiple transcription regulators including HIF-1, c-Fos/Jun, c-Myc/Max and E2F. B. HIF-1 activation is sufficient to upregulate DEC2 levels under normoxic condition. 143B cells were cultured in hypoxia workstation or treated with 100 μM of DFX for 6 h prior to harvest to stabilize HIF-1α. Western blots show HIF-1α stabilization up-regulates DEC2.