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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Int J Mass Spectrom. 2015 Feb 1;377:617–624. doi: 10.1016/j.ijms.2014.06.023

Figure 7. Protein modification strategies for observing extreme N- and C-terminal fragment ions and for enhancing fragmentation by ETD.

Figure 7

(A) Derivatization of the C-terminal carboxyl group (and other acidic residues) with aminoethylbenzimidazole. (B) Derivatization of the amino terminus (and other side chain amino groups) with a protected thiopropionic acid hydroxysuccinimide ester followed by reaction with aminoethylmaleimide.