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. 2015 Mar 24;15:77. doi: 10.1186/s12906-015-0566-y

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© Shen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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LLDT-8 increased the ratio of OPG/RANKL in synovial fluid of RA patients. SFMCs were isolated from synovial fluid of RA patients and treated with various concentrations of LLDT-8 (0, 25 and 50 nM, respectively) for 24 hours, then stained and detected by flow cytometry. (A) The psuedocolor plots of OPG, RANK and RANKL. (B) The rate of OPG expression on CD3⁺ T leukomonocyte in the three groups. (C) The ratio of OPG/RANKL on CD3⁺ T cells in the three groups. *p < 0.05 compared to the control group (0 nM).